LRP5 anticorps (AA 1000-1250)

N° du produit ABIN1513164

Cet anticorps anti-LRP5 est un anticorps Lapin Polyclonal détectant LRP5 dans WB et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour LRP5 anticorps (AA 1000-1250) (ABIN1513164)

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-LRP5 anticorps

Épitope: AA 1000-1250

Séquence: IKRAKDDGTQ PFVLTSLSQG QNPDRQPHDL SIDIYSRTLF WTCEATNTIN VHRLSGEAMG VVLRGDRDKP RAIVVNAERG YLYFTNMQDR AAKIERAALD GTEREVLFTT GLIRPVALVV DNTLGKLFWV DADLKRIESC DLSGANRLTL EDANIVQPLG LTILGKHLYW IDRQQQMIER VEKTTGDKRT RIQGRVAHLT GIHAVEEVSL EEFSAHPCAR DNGGCSHICI AKGDGTPRCS CPVHLVLLQN L

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1250 of human LRP5 (NP_002326.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-LRP5 (ABIN1513164)

Fu, Wang, Wan, Lin, Chang, Han: "Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation." dans: Journal of molecular histology, Vol. 47, Issue 5, pp. 455-66, (2017) (PubMed).

Détails sur LRP5

Antigène: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Autre désignation: LRP5

Sujet: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.,LRP5,BMND1,EVR1,EVR4,HBM,LR3,LRP-5,LRP7,OPPG,OPS,OPTA1,VBCH2,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Cancer,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Microtubules,Extracellular Matrix,Bone,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Neuroscience,Stem Cells,Cardiovascular,Lipids,LRP5

Poids moléculaire: 179 kDa

ID gène: 4041

UniProt: O75197

Pathways: Signalisation WNT, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation