Retinoblastoma Protein (Rb) anticorps (pThr821)

N° du produit ABIN1531516

Cet anticorps Lapin Polyclonal détecte spécifiquement Retinoblastoma Protein (Rb) dans IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Retinoblastoma Protein (Rb) anticorps (pThr821) (ABIN1531516)

Antigène: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma Protein (Rb) est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Retinoblastoma Protein (Rb) anticorps

Épitope: AA 791-840, pThr821

Fonction: Rb (phospho Thr821) Antibody

Specificité: Phospho-Rb (T821) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at T821.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Thr821. AA range:791-840

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Retinoblastoma Protein (Rb)

Antigène: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Sujet:

Synonyms: RB1, Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110

Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],

Gene Name: RB1

Protein Name: Retinoblastoma-associated protein

Poids moléculaire: 106 kDa

ID gène: 5925

OMIM: 109800

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases