BCL2L1 anticorps (pThr115)

N° du produit ABIN1532107

L’anticorps anti-BCL2L1 Polyclonal Lapin est utilisé pour la détection de BCL2L1 dans des échantillons de Humain, Rat et Souris. Il a été validé pour IHC, IF et ELISA.

Aperçu rapide pour BCL2L1 anticorps (pThr115) (ABIN1532107)

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL2L1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Détail du produit anti-BCL2L1 anticorps

Épitope: AA 81-130, pThr115

Fonction: Bcl-x (phospho Thr115) Antibody

Specificité: Phospho-Bcl-x (T115) Polyclonal Antibody detects endogenous levels of Bcl-x protein only when phosphorylated at T115.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human BCL-XL around the phosphorylation site of Thr115. AA range:81-130

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur BCL2L1

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Autre désignation: BCL-XL

Sujet:

Synonyms: BCL2L1, BCL2L, BCLX, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X

Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015],

Gene Name: BCL2L1

Protein Name: Bcl-2-like protein 1

Poids moléculaire: 26 kDa

ID gène: 598

OMIM: 600039

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling