PRKACA/PRKACB anticorps (AA 166-215)

N° du produit ABIN1532391

L’anticorps anti-PRKACA/PRKACB Polyclonal Lapin est utilisé pour la détection de PRKACA/PRKACB dans des échantillons de Humain, Souris, Rat et Porc. Il a été validé pour WB, IHC, IF et ELISA.

Aperçu rapide pour PRKACA/PRKACB anticorps (AA 166-215) (ABIN1532391)

Antigène: PRKACA/PRKACB (PRKACA/B) (Protein Kinase A, alpha/beta (PRKACA/B))

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKACA/PRKACB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Détail du produit anti-PRKACA/PRKACB anticorps

Épitope: AA 166-215

Fonction: PKAα/β/γ cat Antibody

Specificité: PKAα/β/γ cat Polyclonal Antibody detects endogenous levels of PKAα/β/γ cat protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human PKA alpha/beta CAT. AA range:166-215

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur PRKACA/PRKACB

Antigène: PRKACA/PRKACB (PRKACA/B) (Protein Kinase A, alpha/beta (PRKACA/B))

Autre désignation: PKA alpha/beta CAT

Sujet:

Synonyms: PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; PRKACG; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma

Background: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Altern

Gene Name: PRKACA/PRKACB

Protein Name: cAMP-dependent protein kinase catalytic subunit alpha/beta

Poids moléculaire: 40 kDa

ID gène: 5566, 5567

OMIM: 601639

UniProt: P17612