p107 anticorps (AA 335-384)

N° du produit ABIN1532532

Cet anticorps Lapin Polyclonal détecte spécifiquement p107 dans ELISA et IF. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour p107 anticorps (AA 335-384) (ABIN1532532)

Antigène: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p107 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Détail du produit anti-p107 anticorps

Épitope: AA 335-384

Fonction: p107 Antibody

Specificité: P107 Polyclonal Antibody detects endogenous levels of p107 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human RBL1. AA range:335-384

Isotype: IgG

Information d'application

Indications d'application: IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur p107

Antigène: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Autre désignation: RBL1

Sujet:

Synonyms: RBL1, Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1

Background: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought thatThe protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms hav

Gene Name: RBL1

Protein Name: Retinoblastoma-like protein 1

Poids moléculaire: 120 kDa

ID gène: 5933

OMIM: 116957

UniProt: P28749

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases