MMP2 anticorps (AA 611-660)

N° du produit ABIN1533350

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP2 dans WB, IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Rat, Souris et Singe.Il a été cité dans 1 publication.

Aperçu rapide pour MMP2 anticorps (AA 611-660) (ABIN1533350)

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-MMP2 anticorps

Épitope: AA 611-660

Fonction: MMP-2 Antibody

Specificité: MMP-2 Polyclonal Antibody detects endogenous levels of MMP-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human MMP-2. AA range:611-660

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Références pour anticorps anti-MMP2 (ABIN1533350)

Matsumoto, Niimi, Kohyama: "Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis." dans: Cellular immunology, Vol. 279, Issue 1, pp. 70-7, (2012) (PubMed).

Détails sur MMP2

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: MMP-2

Sujet:

Synonyms: MMP2, CLG4A, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1

Background: matrix metallopeptidase 2(MMP2) Homo sapiens This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction.The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Win

Gene Name: MMP2

Protein Name: 72 kDa type IV collagenase

Poids moléculaire: 73 kDa

ID gène: 4313

OMIM: 120360

UniProt: P08253

Pathways: Activation of Innate immune Response