TDG anticorps (AA 31-80)

N° du produit ABIN1533874

L’anticorps anti-TDG Polyclonal Lapin est utilisé pour la détection de TDG dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IF et IHC.

Aperçu rapide pour TDG anticorps (AA 31-80) (ABIN1533874)

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-TDG anticorps

Épitope: AA 31-80

Fonction: TDG Antibody

Specificité: TDG Polyclonal Antibody detects endogenous levels of TDG protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human TDG. AA range:31-80

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: TDG

Sujet:

Synonyms: TDG, G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase

Background: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008],

Gene Name: TDG

Protein Name: G/T mismatch-specific thymine DNA glycosylase

Poids moléculaire: 46 kDa

ID gène: 6996

OMIM: 601423

UniProt: Q13569

Pathways: Réparation de l'ADN, Chromatin Binding