GIT2 anticorps (AA 361-410)

N° du produit ABIN1533883

L’anticorps anti-GIT2 Polyclonal Lapin est utilisé pour la détection de GIT2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC et IF.

Aperçu rapide pour GIT2 anticorps (AA 361-410) (ABIN1533883)

Antigène: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GIT2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GIT2 anticorps

Épitope: AA 361-410

Fonction: GIT2 Antibody

Specificité: GIT2 Polyclonal Antibody detects endogenous levels of GIT2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human GIT2. AA range:361-410

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur GIT2

Antigène: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Autre désignation: GIT2

Sujet:

Synonyms: GIT2, KIAA0148, ARF GTPase-activating protein GIT2, ARF GAP GIT2, Cool-interacting tyrosine-phosphorylated protein 2, CAT-2, CAT2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2

Background: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G

Gene Name: GIT2

Protein Name: ARF GTPase-activating protein GIT2

Poids moléculaire: 84 kDa

ID gène: 9815

OMIM: 608564

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling