PTAFR anticorps (AA 194-243)

N° du produit ABIN1535986

L’anticorps anti-PTAFR Polyclonal Lapin est utilisé pour la détection de PTAFR dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA et IF.

Aperçu rapide pour PTAFR anticorps (AA 194-243) (ABIN1535986)

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTAFR est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Détail du produit anti-PTAFR anticorps

Épitope: AA 194-243

Fonction: PAF-R Antibody

Specificité: PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243

Isotype: IgG

Information d'application

Indications d'application: IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur PTAFR

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Autre désignation: PTAFR

Sujet:

Synonyms: PTAFR, PAFR, Platelet-activating factor receptor, PAF-R, PAFr

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Gene Name: PTAFR

Protein Name: Platelet-activating factor receptor

Poids moléculaire: 39 kDa

ID gène: 5724

OMIM: 173393

UniProt: P25105

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin