CASP5 anticorps (Cleaved-Ser331)

N° du produit ABIN1536106

L’anticorps anti-CASP5 Polyclonal Lapin est utilisé pour la détection de CASP5 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour CASP5 anticorps (Cleaved-Ser331) (ABIN1536106)

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASP5 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CASP5 anticorps

Épitope: AA 312-361, Cleaved-Ser331

Fonction: Cleaved-Caspase-5 p10 (S331) Antibody

Specificité: Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-5 p10 protein resulting from cleavage adjacent to S331.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human Caspase 5. AA range:312-361

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur CASP5

Antigène: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Autre désignation: Caspase 5

Sujet:

Synonyms: CASP5, ICH3, Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010],

Gene Name: CASP5

Protein Name: Caspase5

Poids moléculaire: 10 kDa

ID gène: 838

OMIM: 602665

UniProt: P51878

Pathways: Inflammasome