C1R anticorps (Cleaved-Ile464)

N° du produit ABIN1536124

L’anticorps anti-C1R Polyclonal Lapin est utilisé pour la détection de C1R dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et ELISA.

Aperçu rapide pour C1R anticorps (Cleaved-Ile464) (ABIN1536124)

Antigène: C1R (Complement Component 1, R Subcomponent (C1R))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C1R est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-C1R anticorps

Épitope: AA 445-494, Cleaved-Ile464

Fonction: Cleaved-C1r LC (I464) Antibody

Specificité: Cleaved-C1r LC (I464) Polyclonal Antibody detects endogenous levels of fragment of activated C1r LC protein resulting from cleavage adjacent to I464.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human C1R. AA range:445-494

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur C1R

Antigène: C1R (Complement Component 1, R Subcomponent (C1R))

Autre désignation: C1R

Sujet:

Synonyms: C1R, Complement C1r subcomponent, Complement component 1 subcomponent r

Background: catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,

Gene Name: C1R

Protein Name: Complement C1r subcomponent

Poids moléculaire: 27 kDa

ID gène: 715

OMIM: 216950

UniProt: P00736

Pathways: Système du Complément