NOTCH4 anticorps (Cleaved-Val1432)

N° du produit ABIN1536151

L’anticorps anti-NOTCH4 Polyclonal Lapin est utilisé pour la détection de NOTCH4 dans des échantillons de Humain, Souris et Singe. Il a été validé pour WB et ELISA.

Aperçu rapide pour NOTCH4 anticorps (Cleaved-Val1432) (ABIN1536151)

Antigène: NOTCH4 (Notch 4 (NOTCH4))

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOTCH4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NOTCH4 anticorps

Épitope: AA 1401-1450, Cleaved-Val1432

Fonction: Cleaved-Notch 4 (V1432) Antibody

Specificité: Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human NOTCH4. AA range:1401-1450

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur NOTCH4

Antigène: NOTCH4 (Notch 4 (NOTCH4))

Autre désignation: NOTCH4

Sujet:

Synonyms: NOTCH4, INT3, Neurogenic locus notch homolog protein 4, Notch 4, hNotch4

Background: notch 4(NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which

Gene Name: NOTCH4

Protein Name: Neurogenic locus notch homolog protein 4

Poids moléculaire: 59 kDa

ID gène: 4855

OMIM: 164951

UniProt: Q99466

Pathways: Signalisation Notch