Macrophage Scavenger Receptor 1 anticorps (C-Term)

N° du produit ABIN1537159

Cet anticorps Lapin Polyclonal détecte spécifiquement Macrophage Scavenger Receptor 1 dans WB. Il présente une réactivité envers Humain et Souris et a été mentionné dans 1 publication.

Aperçu rapide pour Macrophage Scavenger Receptor 1 anticorps (C-Term) (ABIN1537159)

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB36746

Détail du produit anti-Macrophage Scavenger Receptor 1 anticorps

Épitope: AA 336-364, C-Term

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human MSR1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: MSR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-Macrophage Scavenger Receptor 1 (ABIN1537159)

Chen, Li, Zhu: "AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-?B/LOX-1 pathway." dans: Vascular pharmacology, (2015) (PubMed).

Détails sur Macrophage Scavenger Receptor 1

Antigène: Macrophage Scavenger Receptor 1 (MSR1)

Autre désignation: MSR1

Sujet: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Poids moléculaire: 49762

ID gène: 4481

NCBI Accession: NP_002436, NP_619729, NP_619730

UniProt: P21757