STK4 anticorps (C-Term)

N° du produit ABIN1537341

Détail du produit anti-STK4 anticorps

Antigène: STK4 (serine/threonine Kinase 4 (STK4))

Épitope: AA 443-470, C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK4 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Stk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-470 amino acids from the C-terminal region of mouse Stk4.

Clone: RB37147

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Mouse Stk4 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur STK4

Antigène: STK4 (serine/threonine Kinase 4 (STK4))

Autre désignation: Stk4 (STK4 Produits)

Synonymes: anticorps KRS2, anticorps MST1, anticorps TIIAC, anticorps YSK3, anticorps AI447339, anticorps AU020804, anticorps Kas-2, anticorps Mst1, anticorps Ysk3, anticorps krs2, anticorps mst1, anticorps ysk3, anticorps serine/threonine kinase 4, anticorps serine/threonine kinase 4 S homeolog, anticorps STK4, anticorps Stk4, anticorps stk4.S

Sujet: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.

Poids moléculaire: 55541

ID gène: 58231

NCBI Accession: NP_067395

UniProt: Q9JI11

Pathways: Tube Formation