RAD50 anticorps (C-Term)

N° du produit ABIN1537647

Cet anticorps anti-RAD50 est un anticorps Lapin Polyclonal détectant RAD50 dans WB. Adapté pour Souris.

Aperçu rapide pour RAD50 anticorps (C-Term) (ABIN1537647)

Antigène: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD50 est non-conjugé

Application: Western Blotting (WB)

Clone: RB40014

Détail du produit anti-RAD50 anticorps

Épitope: AA 911-938, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Rad50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-938 amino acids from the C-terminal region of mouse Rad50.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Mouse Rad50 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur RAD50

Antigène: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Autre désignation: Rad50

Sujet: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).

Poids moléculaire: 153488

ID gène: 19360

UniProt: P70388

Pathways: Réparation de l'ADN, Protein targeting to Nucleus