KDM5D anticorps

N° du produit ABIN1589829

Cet anticorps anti-KDM5D est un anticorps Lapin Polyclonal détectant KDM5D dans WB. Adapté pour Humain.

Aperçu rapide pour KDM5D anticorps (ABIN1589829)

Antigène: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM5D est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KDM5D anticorps

Fonction: SMCY/JARID1D antibody

Specificité: Recombinant human SMCY

Attributs du produit: Chromosomal location: Yq11, Yq11

Purification: Protein A purified

Immunogène: Recombinant human SMCY

Isotype: IgG

Information d'application

Indications d'application: Western Blot: Use 1-5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening.

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Date de péremption: 24 months

Détails sur KDM5D

Antigène: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Autre désignation: SMCY/JARID1D

Sujet: KDM5D lysine (K)-specific demethylase 5D, HY, HYA,H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.

ID gène: 8284

NCBI Accession: NM_001146705, NP_001140177

UniProt: Q9BY66

Pathways: L'effet Warburg