KDM5D anticorps

N° du produit ABIN1589829

Détail du produit anti-KDM5D anticorps

Antigène: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM5D est non-conjugé

Application: Western Blotting (WB)

Specificité: Recombinant human SMCY

Attributs du produit: Chromosomal location: Yq11, Yq11

Isotype: IgG

Information d'application

Indications d'application: Western Blot: use 1-5 µg/mL

Commentaires:

Rabbit IG Polyclonal Antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening.

Stock: -20 °C

Stockage commentaire: The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.

Date de péremption: 6 months

Détails sur KDM5D

Antigène: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Autre désignation: SMCY/JARID1D (KDM5D Produits)

Synonymes: anticorps JARID1D, anticorps Jarid1d, anticorps DKFZp468I1010, anticorps HY, anticorps HYA, anticorps SMCY, anticorps Smcy, anticorps lysine demethylase 5D, anticorps lysine (K)-specific demethylase 5D, anticorps lysine demethylase 5C, anticorps KDM5D, anticorps Kdm5d, anticorps KDM5C

Sujet: H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.
Synonyms: KDM5D lysine (K)-specific demethylase 5D, HY, HYA

NCBI Accession: NM_001146705, NP_001140177

UniProt: Q9BY66

Pathways: L'effet Warburg