TEK anticorps

N° du produit ABIN1589890

Cet anticorps Lapin Polyclonal détecte spécifiquement TEK dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour TEK anticorps (ABIN1589890)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TEK anticorps

Fonction: TIE-2 antibody

Specificité: Recombinant human sTIE-2

Attributs du produit: Chromosomal location: 9p21

Purification: Protein A purified

Immunogène: Recombinant human sTIE-2 (ABIN1589753)

Isotype: IgG

Information d'application

Indications d'application: Western Blot: Use 2-5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening.

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Date de péremption: 24 months

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: TIE-2

Sujet: TEK, TIE2, VMCM, TIE-2, VMCM1, CD202B,TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/TEK comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2), which bind TIE-2 with high affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or TIE-2 display similar angiogenic defects.

ID gène: 7010

NCBI Accession: NM_000459, NP_000450

UniProt: Q02763

Pathways: Signalisation RTK, Growth Factor Binding