APP anticorps (N-Term)

N° du produit ABIN1607880

N° du produit (Fournisseur): 600-401-j13

Cet anticorps anti-APP est un anticorps Lapin Polyclonal détectant APP dans WB, ELISA, IHC et FM. Adapté pour Humain et Primate.

Aperçu rapide pour APP anticorps (N-Term) (ABIN1607880)

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivité: Humain, Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Détail du produit anti-APP anticorps

Épitope: N-Term

N° du produit (Fournisseur): 600-401-j13

Fournisseur: Rockland

Fonction: Beta Amyloid pyro E11 Antibody

Réactivité croisée (Details): This antibody is specific to the N-terminus 11-pyro E start point.

Attributs du produit: Synonyms: rabbit anti-Beta Amyloid pyro E11 Antibody, ß-amyloid pyro E11, Alzheimer disease amyloid protein, Beta amyloid, A-beta, ABPP, APPI

Purification: Anti-Beta Amyloid pyro Glu11 was affinity purified from monospecific antiserum by immunoaffinity chromatography.

Stérilité: Sterile filtered

Immunogène:

Immunogen: beta Amyloid [Pyro Glu11] affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the N-terminus 11-pyro E start point of human beta Amyloid.

Immunogen Type: Conjugated Peptide

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 1:100-1:500

Application Note: Anti-Beta Amyloid pyro Glu11 antibody has been tested by western blot and is useful for ELISA, Western Blot and Immunostaining. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~86.9 kDa corresponding to the appropriate cell lysate or extract.

Western Blot Dilution: 0.2 μg/mL

ELISA Dilution: 1:20,000 - 1:60,000

IF Microscopy Dilution: 1:100-1:500

Other: User Optimized

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 30 % Glycerol

Preservative: None

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 6 months

Détails sur APP

Antigène: APP (Amyloid beta (A4) Precursor Protein (APP))

Autre désignation: APP

Sujet: Background: The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. Beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. Beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. Beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. Beta Amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease. Anti-beta Amyloid [Pyro Glu11] antibody is ideal for researchers interested Alzheimer's Research, Cell Cycle and Replication, and Neuroscience research.

ID gène: 351

NCBI Accession: NP_000475

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour