Nibrin anticorps (AA 435-754)

N° du produit ABIN1681204

Détail du produit anti-Nibrin anticorps

Antigène: Nibrin (NBN)

Épitope: AA 435-754

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: KLPSINKSKD RASQQQQTNS IRNYFQPSTK KRERDEENQE MSSCKSARIE TSCSLLEQTQ PATPSLWKNK EQHLSENEPV DTNSDNNLFT DTDLKSIVKN SASKSHAAEK LRSNKKREMD DVAIEDEVLE QLFKDTKPEL EIDVKVQKQE EDVNVRKRPR MDIETNDTFS DEAVPESSKI SQENEIGKKR ELKEDSLWSA KEISNNDKLQ DDSEMLPKKL LLTEFRSLVI KNSTSRNPSG INDDYGQLKN FKKFKKVTYP GAGKLPHIIG GSDLIAHHAR KNTELEEWLR QEMEVQNQHA KEESLADDLF RYNPYLKRRR

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 435-754 of human NBS1/NBS1/NBN (NP_002476.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-Nibrin (ABIN1681204)

Li, Zhang, Chen, Guo, Zhang, Tang, Xu, Zhang, Tao, Wang, Jiang, Sun, Mao: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." dans: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).

Zhang, Tang, Jiang, Mao: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." dans: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: NBN (NBN Produits)

Synonymes: anticorps NBN, anticorps AT-V1, anticorps AT-V2, anticorps ATV, anticorps NBS, anticorps NBS1, anticorps P95, anticorps Nbs1, anticorps im:6911679, anticorps zgc:194152, anticorps nibrin, anticorps NBN, anticorps nbn, anticorps Nbn

Sujet: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.,NBN,AT-V1,AT-V2,ATV,NBS,NBS1,P95,nibrin,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,G2/M DNA Damage Checkpoint,NBN

Poids moléculaire: 84 kDa

ID gène: 4683

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response