CD200 anticorps (PE)

N° du produit ABIN1690744

Cet anticorps Souris Monoclonal détecte spécifiquement CD200 dans FACS. Il présente une réactivité envers Humain et a été mentionné dans 7+ publications.

Aperçu rapide pour CD200 anticorps (PE) (ABIN1690744)

Antigène: CD200

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD200 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: OX-104

Détail du produit anti-CD200 anticorps (PE)

Fonction: Anti-Hu CD200 PE

Specificité: The mouse monoclonal antibody OX-104 recognizes an extracellular epitope of CD200, a type-1 glycoprotein of the immunoglobulin superfamily, which is expressed in neurons, B and T cell subsets, keratinocytes, follicular dendritic cells, and ovarian cells.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: recombinant human CD200

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Stockage

Reconstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.
Avoid prolonged exposure to light.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD200 (PE) (ABIN1690744)

Colmont, Benketah, Reed, Hawk, Telford, Ohyama, Udey, Yee, Vogel, Patel: "CD200-expressing human basal cell carcinoma cells initiate tumor growth." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 4, pp. 1434-9, (2013) (PubMed).

Li, Zhao, Tong, Qian, Ren, Zhang, Ding, Chen, Wang, Zhang, Zeng, Zhang, Tang, Zhang, Ba, He, Cao, Lipsky: "Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity." dans: Arthritis research & therapy, Vol. 14, Issue 3, pp. R123, (2012) (PubMed).

Garza, Yang, Zhao, Blatt, Lee, He, Stanton, Carrasco, Spiegel, Tobias, Cotsarelis: "Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells." dans: The Journal of clinical investigation, Vol. 121, Issue 2, pp. 613-22, (2011) (PubMed).

Meuth, Simon, Grimm, Melzer, Herrmann, Spitzer, Landgraf, Wiendl: "CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing." dans: Journal of neuroimmunology, Vol. 194, Issue 1-2, pp. 62-9, (2008) (PubMed).

Sopp, Werling, Baldwin: "Cross-reactivity of mAbs to human CD antigens with cells from cattle." dans: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 106-14, (2007) (PubMed).

Shiratori, Yamaguchi, Suzukawa, Yamamoto, Lanier, Saito, Arase: "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 7, pp. 4441-9, (2005) (PubMed).

Foster-Cuevas, Wright, Puklavec, Brown, Barclay: "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor." dans: Journal of virology, Vol. 78, Issue 14, pp. 7667-76, (2004) (PubMed).

Détails sur CD200

Antigène: CD200

Autre désignation: CD200

Sujet: CD200 Molecule,CD200 (also known as OX2 or MRC) is a type-1 membrane glycoprotein, which contains two extracellular immunoglobulin domains, transmembrane domain and cytoplasmic domain. It is expressed by neuronal cells, B and T cell subsets, follicular dendritic cells, keratinocytes, and ovarian cells. The interaction between CD200 and its receptor CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation along with reduced TNF-alpha and IL-13 secretion and overall attenuation of the activation status of lymphocytes. It seems CD200 is also involved in maternal tolerance and its decreased expression in hair follicle correlates with follicular miniaturization.,MRC, MOX, OX-2

ID gène: 4345

UniProt: P41217