Glutaredoxin 2 anticorps (AA 101-164) (AbBy Fluor® 350)

N° du produit ABIN1693781

L’anticorps Lapin Polyclonal anti-Glutaredoxin 2 a été validé pour WB, FACS, IF (cc) et IF (p). Il convient pour détecter Glutaredoxin 2 dans des échantillons de Humain et Rat.

Aperçu rapide pour Glutaredoxin 2 anticorps (AA 101-164) (AbBy Fluor® 350) (ABIN1693781)

Antigène: Glutaredoxin 2 (GRX2)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutaredoxin 2 est conjugé à/à la AbBy Fluor® 350

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Glutaredoxin 2 anticorps (AbBy Fluor® 350)

Épitope: AA 101-164

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Glutaredoxin 2

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Glutaredoxin 2

Antigène: Glutaredoxin 2 (GRX2)

Autre désignation: Glutaredoxin 2

Sujet:

Synonyms: GRX2, CGI-133, Glutaredoxin-2, mitochondrial, GLRX2

Background: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

ID gène: 51022

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis