GLDC anticorps (AA 51-150) (AbBy Fluor® 488)

N° du produit ABIN1695510

Cet anticorps anti-GLDC est un anticorps Lapin Polyclonal détectant GLDC dans WB, IF (cc) et IF (p). Adapté pour Humain.

Aperçu rapide pour GLDC anticorps (AA 51-150) (AbBy Fluor® 488) (ABIN1695510)

Antigène: GLDC (Glycine Dehydrogenase (GLDC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLDC est conjugé à/à la AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-GLDC anticorps (AbBy Fluor® 488)

Épitope: AA 51-150

Homologie: Human,Mouse,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GLDC

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GLDC

Antigène: GLDC (Glycine Dehydrogenase (GLDC))

Autre désignation: GLDC

Sujet:

Synonyms: GCE, GCSP, GCSP_HUMAN, GLDC, Glycine cleavage system P protein, glycine cleavage system protein P, Glycine decarboxylase, glycine decarboxylase P protein, Glycine dehydrogenase decarboxylating mitochondrial, Glycine dehydrogenase [decarboxylating], mitochondrial, Gycine dehydrogenase decarboxylating, HYGN1, MGC138198, MGC138200, NKH.

Background: The glycine cleavage system is comprised of AMT (known as Protein T), GCSH (known as Protein H), DLD (known as Protein L) and GLDC (known as Protein P), all of which work together to catalyze the cleavage and degradation of glycine. GLDC (glycine dehydrogenase ), also known as GCE, GCSP (glycine cleavage system P protein) or HYGN1, is a 1,020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family. GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T. GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor. Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

ID gène: 2731