FAN1 anticorps (AbBy Fluor® 647)

N° du produit ABIN1698843

Cet anticorps anti-FAN1 est un anticorps Lapin Polyclonal détectant FAN1 dans IF (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour FAN1 anticorps (AbBy Fluor® 647) (ABIN1698843)

Antigène: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAN1 est conjugé à/à la AbBy Fluor® 647

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-FAN1 anticorps (AbBy Fluor® 647)

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FAN1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 4°C

Date de péremption: 12 months

Détails sur FAN1

Antigène: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Autre désignation: Fan1

Sujet:

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Subcellular location: Nucleus

Synonyms: KMIN, hFAN1, MTMR15, KIAA1018, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, FAN1

ID gène: 22909

UniProt: Q9Y2M0

Pathways: Réparation de l'ADN