VAV3 anticorps (pTyr141) (AbBy Fluor® 647)

N° du produit ABIN1699095

Cet anticorps anti-VAV3 est un anticorps Lapin Polyclonal détectant VAV3 dans WB, IF (cc) et IF (p). Adapté pour Souris et Rat.

Aperçu rapide pour VAV3 anticorps (pTyr141) (AbBy Fluor® 647) (ABIN1699095)

Antigène: VAV3 (Vav 3 Oncogene (VAV3))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAV3 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-VAV3 anticorps (AbBy Fluor® 647)

Épitope: pTyr141

Réactivité croisée: Souris, Rat

Homologie: Human,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur VAV3

Antigène: VAV3 (Vav 3 Oncogene (VAV3))

Autre désignation: VAV3

Sujet:

Synonyms: VAV3phospho Y141, Guanine nucleotide exchange factor VAV3, Protein vav 3, Protein vav3, VAV 3, Vav 3 guanine nucleotide exchange factor, VAV 3 oncogene, VAV 3 protein, VAV-3, Vav3, VAV3 oncogene, VAV3 protein, VAV3_HUMAN.

Background: The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge, Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

ID gène: 10451

Pathways: Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway