ODF2 anticorps (AA 1-100) (Biotin)

N° du produit ABIN1700061

Cet anticorps anti-ODF2 est un anticorps Lapin Polyclonal détectant ODF2 dans WB, ELISA, IHC (p) et IHC (fro). Adapté pour Rat.

Aperçu rapide pour ODF2 anticorps (AA 1-100) (Biotin) (ABIN1700061)

Antigène: ODF2 (Outer Dense Fiber of Sperm Tails 2 (ODF2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ODF2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ODF2 anticorps (Biotin)

Épitope: AA 1-100

Réactivité croisée: Rat

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ODF2/Cenexin1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ODF2

Antigène: ODF2 (Outer Dense Fiber of Sperm Tails 2 (ODF2))

Autre désignation: ODF2/Cenexin1

Sujet:

Synonyms: sperm tail structural protein, 84 kDa outer dense fiber protein, Cenexin 1, Cenexin1 variant 1, KKT 4, KKT4, ODF 2, ODF 84, ODF2, ODF2/1, ODF2/2, ODF84, Outer dense fiber of sperm tail 2, Outer dense fiber of sperm tails 2, outer dense fiber of sperm tails, Outer dense fiber of sperm tails protein 2, Outer dense fiber of sperm tails, 84 kD, Outer dense fiber protein 2, Sperm outer dense fiber major protein 2, Testis specic autoantigen, ODFP2_HUMAN.

Background: Cenexin1 is an isoform of ODF2, that unlike ODF2 is present in several somatic cell types. Cenexin1 acts as a general scaffold protein that is specifically localised to the distal/subdistal appendages of mother centrioles. Cenexin1 is required for proper localization of Plk1 to the centrosomes. This centrosomal localization of Plk1 is required for proper microtubule function. Cenexin1 recruits Plk1 via a C-terminal extension of cenexin1 that is not present in ODF2. Cenexin1 is required for proper mitotic progression, depletion of Cenexin1 µLtimately leads to chromosome missegregation and apoptosis. The ODF2 (outer dense fiber 2) gene encodes both ODF2 and Cenexin1, which have very different functions. ODF2 is a major component of sperm tail outer dense fibers (ODFs). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. They may help to maintain the passive elastic structures and elastic recoil of the sperm tail, and may also modulate sperm motility.

ID gène: 4957

Pathways: M Phase