TOM1L1 anticorps (AA 1-100) (Biotin)

N° du produit ABIN1700080

Cet anticorps Lapin Polyclonal détecte spécifiquement TOM1L1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour TOM1L1 anticorps (AA 1-100) (Biotin) (ABIN1700080)

Antigène: TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOM1L1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-TOM1L1 anticorps (Biotin)

Épitope: AA 1-100

Homologie: Human,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TOM1L1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TOM1L1

Antigène: TOM1L1 (Target of Myb1 (Chicken)-Like 1 (TOM1L1))

Autre désignation: TOM1L1

Sujet:

Synonyms: OK/KNS CL.3, Src activating and signaling molecule, Src activating and signaling molecule protein, Src-activating and signaling molecule protein, SRCASM, Target of Myb like protein 1, Target of Myb-like protein 1, Target of myb1 chicken homolog like 1, Target of myb1 chicken like 1, Target of myb1 like 1, TM1L1_HUMAN, TOM1 L1, TOM1 like protein 1, TOM1-like protein 1, TOM1L1, TOM1L1 protein.

Background: Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.