PRAM1 anticorps (AA 551-650) (Biotin)

N° du produit ABIN1700382

Cet anticorps anti-PRAM1 est un anticorps Lapin Polyclonal détectant PRAM1 dans ELISA, IHC (p) et IHC (fro). Adapté pour Humain.

Aperçu rapide pour PRAM1 anticorps (AA 551-650) (Biotin) (ABIN1700382)

Antigène: PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRAM1 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PRAM1 anticorps (Biotin)

Épitope: AA 551-650

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PRAM1

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PRAM1

Antigène: PRAM1 (PML-RARA Regulated Adaptor Molecule 1 (PRAM1))

Autre désignation: PRAM1

Sujet:

Synonyms: PML RAR, PML RARA regulated adaptor molecule 1, PML RARA target gene encoding an Adaptor Molecule 1, PML-RARA-regulated adapter molecule 1, PRAM 1, PRAM, PRAM-1, PRAM_HUMAN, PRAM1.

Background: Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung.

Pathways: Regulation of Leukocyte Mediated Immunity