CYB5R3 anticorps (Cy5)

N° du produit ABIN1704261

Détail du produit anti-CYB5R3 anticorps (Cy5)

Antigène: CYB5R3 (Cytochrome B5 Reductase 3 (CYB5R3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYB5R3 est conjugé à/à la Cy5

Application: Western Blotting (WB)

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CYB5R3

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CYB5R3

Antigène: CYB5R3 (Cytochrome B5 Reductase 3 (CYB5R3))

Autre désignation: Cyb5r3 (CYB5R3 Produits)

Synonymes: anticorps B5R, anticorps DIA1, anticorps Dia1, anticorps Nadhcb5, anticorps RNNADHCB5, anticorps 0610016L08Rik, anticorps 2500002N19Rik, anticorps C85115, anticorps Dia-1, anticorps WU:AL591952.1-001, anticorps WU:AL591952.1-002, anticorps WU:AL591952.1-003, anticorps WU:Cyb5r3, anticorps fc32h03, anticorps zgc:77071, anticorps wu:fc32h03, anticorps dia1, anticorps CB5R, anticorps DDBDRAFT_0218707, anticorps DDBDRAFT_0266821, anticorps DDB_0218707, anticorps DDB_0266821, anticorps cytochrome b5 reductase 3, anticorps cytochrome b5 reductase 3 L homeolog, anticorps NADH-cytochrome b5 reductase, anticorps CYB5R3, anticorps Cyb5r3, anticorps cyb5r3, anticorps cyb5r3.L, anticorps CNM00240, anticorps Tb11.47.0018, anticorps cyb5r1

Sujet:

Synonyms: B5R, Cyb5r3, Cytochrome b5 reductase 3, Cytochrome b5 reductase, DIA1, Diaphorase 1, Diaphorase-1, NADH cytochrome b5 reductase 3, NADH-cytochrome b5 reductase 3 membrane-bound form, NADH-cytochrome b5 reductase 3 soluble form, NB5R3_HUMAN, OTTHUMP00000028761, OTTHUMP00000198435, OTTHUMP00000198574, OTTHUMP00000198662, OTTHUMP00000198665.

Background: CYB5R3 is a 301 amino acid protein encoded by the human gene CYB5R3. CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in erythrocytes. CYB5R3 is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. A serine residue at position 117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It is not found in Caucasians, Asians, Indo-Aryans or Arabs. This difference seems to have no effect on the enzyme activity. Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM). There are three forms of this disease: type 1 (HM1), in which the enzyme is only deficient in erythrocytes with a mild cyanosis, type 2 (HM2), in which the enzyme is completely deficient, and type 3 (HM3), where the deficiency is seen in all blood cells. Type 2 is a severe form accompanied by mental retardation and neurological impairment.

ID gène: 1727

Pathways: SARS-CoV-2 Protein Interactome