BOP1 anticorps (AA 201-300) (Cy7)

N° du produit ABIN1708008

Cet anticorps anti-BOP1 est un anticorps Lapin Polyclonal détectant BOP1 dans WB, IF (cc) et IF (p). Adapté pour Souris.

Aperçu rapide pour BOP1 anticorps (AA 201-300) (Cy7) (ABIN1708008)

Antigène: BOP1 (Block of Proliferation 1 (BOP1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BOP1 est conjugé à/à la Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-BOP1 anticorps (Cy7)

Épitope: AA 201-300

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BOP1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BOP1

Antigène: BOP1 (Block of Proliferation 1 (BOP1))

Autre désignation: BOP1

Sujet:

Synonyms: AU020183, AW146150, Block of proliferation 1, Block of proliferation 1 protein, Bop1, Bop1 block of proliferation 1, BOP1_HUMAN, D18861, Erb1p, Kiaa0124, MGC109114, mKIAA0124, Ribosome biogenesis protein BOP1.

Background: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.

ID gène: 23246