BLM anticorps (AA 1201-1417) (Cy7)

N° du produit ABIN1708558

Cet anticorps Lapin Polyclonal détecte spécifiquement BLM dans WB, IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour BLM anticorps (AA 1201-1417) (Cy7) (ABIN1708558)

Antigène: BLM (Bloom Syndrome RecQ Like Helicase (BLM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BLM est conjugé à/à la Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-BLM anticorps (Cy7)

Épitope: AA 1201-1417

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BLM

Antigène: BLM (Bloom Syndrome RecQ Like Helicase (BLM))

Autre désignation: BLM/Blooms Syndrome Protein Blm

Sujet:

Synonyms: BLM, BLM_HUMAN, Bloom Syndrome, Bloom syndrome protein, Bloom syndrome RecQ helicase like, BS, DNA Helicase, DNA helicase RecQ like type 2, MGC126616, MGC131618, MGC131620, RECQ 2, RECQ like, RecQ like type 2, RecQ protein like 3, RecQ Protein-like 3, RECQ-2, RECQ-Like, RecQ-like type 2, RECQ2, RECQL 2, RECQL 3, RECQL-2, RECQL-3, RECQL2, RECQL3, type 2.

Background: Bloom?s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom?s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom?s syndrome patients. One characteristic of Bloom?s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom?s cells.

ID gène: 641

Pathways: Réparation de l'ADN