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FANCM anticorps (AA 831-930) (HRP)

FANCM Reactivité: Humain IHC (fro), IHC (p) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1711008
  • Antigène Voir toutes FANCM Anticorps
    FANCM (Fanconi Anemia Complementation Group M (FANCM))
    Épitope
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 831-930
    Reactivité
    • 27
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 25
    • 2
    • 1
    Lapin
    Clonalité
    • 28
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FANCM est conjugé à/à la HRP
    Application
    • 13
    • 13
    • 11
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human FANCM
    Isotype
    IgG
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Date de péremption
    12 months
  • Antigène
    FANCM (Fanconi Anemia Complementation Group M (FANCM))
    Autre désignation
    FANCM (FANCM Produits)
    Synonymes
    anticorps FAAP250, anticorps KIAA1596, anticorps AI427100, anticorps C730036B14Rik, anticorps D12Ertd364e, anticorps Fanconi anemia complementation group M, anticorps hypothetical protein, anticorps Fanconi anemia, complementation group M, anticorps FANCM, anticorps PGTG_17854, anticorps Fancm
    Sujet

    Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.

    Subcellular location: Nucleus

    Synonyms: FAAP250, Fanconi anemia group M protein, Protein Hef ortholog,

    ID gène
    57697
    Pathways
    Réparation de l'ADN
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