GCAP1 anticorps (AA 51-150) (HRP)

N° du produit ABIN1712059

Cet anticorps Lapin Polyclonal détecte spécifiquement GCAP1 dans ELISA, WB, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour GCAP1 anticorps (AA 51-150) (HRP) (ABIN1712059)

Antigène: GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GCAP1 est conjugé à/à la HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GCAP1 anticorps (HRP)

Épitope: AA 51-150

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GCAP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GCAP1

Antigène: GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

Autre désignation: GCAP1

Sujet:

Synonyms: COD3, GCAP 1, GCAP, Guanylate Cyclase Activating Protein Photoreceptor 1, Guanylate Cyclase Activating Protein Photoreceptor 1, Guanylate Cyclase Activator 1A, Guanylate Cyclase Activator 1A, Guanylin 1, Guanylin 1, guanylyl cyclase activating protein 1, Guanylyl cyclase-activating protein 1, GUC1A_HUMAN, GUCA, GUCA1, GUCA1A, GUCA1A.

Background: intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90 % similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.

ID gène: 2978

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction