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HHATL anticorps (AA 25-125) (HRP)

HHATL Reactivité: Humain WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1712346
  • Antigène Voir toutes HHATL Anticorps
    HHATL (Hedgehog Acyltransferase-Like (HHATL))
    Épitope
    • 14
    • 2
    • 1
    AA 25-125
    Reactivité
    • 17
    • 2
    • 2
    Humain
    Hôte
    • 16
    • 1
    Lapin
    Clonalité
    • 16
    • 1
    Polyclonal
    Conjugué
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HHATL est conjugé à/à la HRP
    Application
    • 13
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HHATL/GUP1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Date de péremption
    12 months
  • Antigène
    HHATL (Hedgehog Acyltransferase-Like (HHATL))
    Autre désignation
    HHATL/GUP1 (HHATL Produits)
    Synonymes
    anticorps Gup1, anticorps RGD1311911, anticorps gup1, anticorps oact3, anticorps mboat3, anticorps MGC53261, anticorps mstp002, anticorps MGC89797, anticorps GUP1, anticorps 1110011D13Rik, anticorps C3orf3, anticorps MBOAT3, anticorps MSTP002, anticorps OACT3, anticorps c3orf3b, anticorps gup1b, anticorps im:7145545, anticorps wu:fc04e05, anticorps zgc:154131, anticorps c3orf3a, anticorps gup1a, anticorps zgc:77750, anticorps hedgehog acyltransferase-like, anticorps hedgehog acyltransferase like S homeolog, anticorps hedgehog acyltransferase like, anticorps hedgehog acyltransferase like, b, anticorps hedgehog acyltransferase like, a, anticorps Hhatl, anticorps hhatl.S, anticorps HHATL, anticorps hhatl, anticorps hhatlb, anticorps hhatla
    Sujet

    GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.

    Subcellular location: Cytoplasm, Cell membrane

    Synonyms: C3orf3, Glycerol uptake/transporter homolog, GUP1, GUP1 glycerol uptake/transporter homolog, Hedgehog acyltransferase like, Hedgehog acyltransferase-like protein, Hhatl, HHATL_HUMAN, KIAA1173, MBOAT3, Membrane bound O acyltransferase domain containing 3, MSTP002, OACT3, Protein-cysteine N-palmitoyltransferase HHAT-like protein.

    ID gène
    57467
    Pathways
    Signalisation Hedgehog
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