Girdin anticorps (pTyr1765)

N° du produit ABIN1713601

Détail du produit anti-Girdin anticorps

Antigène: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Épitope: pTyr1765

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Girdin est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human APE around the phosphorylation site of Tyr1765

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Girdin

Antigène: Girdin (CCDC88A) (Coiled-Coil Domain Containing 88A (CCDC88A))

Autre désignation: Girdin (CCDC88A Produits)

Synonymes: anticorps APE, anticorps GIRDIN, anticorps GIV, anticorps GRDN, anticorps HkRP1, anticorps KIAA1212, anticorps A430106J12Rik, anticorps AI848406, anticorps Ape, anticorps C130096N06Rik, anticorps C330012F17Rik, anticorps D130005J21Rik, anticorps Girdin, anticorps Giv, anticorps Grdn, anticorps Hkrp1, anticorps DKFZp459N1815, anticorps RGD1306694, anticorps coiled-coil domain containing 88A, anticorps coiled coil domain containing 88A, anticorps CCDC88A, anticorps Ccdc88a

Sujet:

Synonyms: Girdin phospho Y1765, p-Girdin phospho Y1765, Akt phosphorylation enhancer, APE, Coiled coil domain containing protein 88A, G alpha interacting vesicle associated protein, Girders of actin filament, GIV, HkRP1, Hook related protein 1, AKT iphosphorylation enhancer, Akt phosphorylation enhancer, Ccdc88a, GIV, GRDN, GRDN_HUMAN, HkRP1, Hook related protein 1, Hook-related protein 1, KIAA1212.

Background: Girdin is a 1,871 amino acid protein that, via interactions with phosphoinositides, localizes to the cell membrane and to the cytosol. Expressed ubiquitously, girdin functions to enhance the activity of PI 3-kinase-dependent phosphorylation of proteins, such as Akt1, thereby inducing the phosphorylation of downstream protein targets and, ultimately, regulating DNA replication and cellular proliferation. Additionally, girdin is crucial for cell migration and is responsible for both maintaining the structural integrity of the Actin cytoskeleton and for regulating the formation of Actin stress fibers. Girdin exists as a homodimer that can itself be phosphorylatedan event that delocalizes girdin from the cell membrane, thus allowing it to participate in cell migration events. Two isoforms of girdin exist due to alternative splicing events.

ID gène: 55704