FZD3 anticorps (AA 121-220)

N° du produit ABIN1714171

Cet anticorps Lapin Polyclonal détecte spécifiquement FZD3 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris, Rat et Xenopus laevis et a été mentionné dans 1 publication.

Aperçu rapide pour FZD3 anticorps (AA 121-220) (ABIN1714171)

Antigène: FZD3 (Frizzled Family Receptor 3 (FZD3))

Reactivité: Humain, Souris, Rat, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-FZD3 anticorps

Épitope: AA 121-220

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FZD3/Frizzled 3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-FZD3 (ABIN1714171)

Su, Zhang, Gan, Jiang, Xiao, Zou, Li, Jiang: "Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." dans: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).

Détails sur FZD3

Antigène: FZD3 (Frizzled Family Receptor 3 (FZD3))

Autre désignation: FZD3/Frizzled 3

Sujet:

Synonyms: Fz-3, Frizzled-3, hFz3, FZD3

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

ID gène: 7976

UniProt: Q9NPG1

Pathways: Signalisation WNT, Tube Formation