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FZD3 anticorps (AA 121-220)

FZD3 Reactivité: Humain, Souris, Rat, Xenopus laevis WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714171
  • Antigène Voir toutes FZD3 Anticorps
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Épitope
    • 14
    • 9
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-220
    Reactivité
    • 59
    • 38
    • 23
    • 14
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Xenopus laevis
    Hôte
    • 52
    • 4
    • 3
    • 3
    Lapin
    Clonalité
    • 56
    • 6
    Polyclonal
    Conjugué
    • 30
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FZD3 est non-conjugé
    Application
    • 41
    • 29
    • 12
    • 12
    • 11
    • 10
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Homologie
    Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human FZD3/Frizzled 3
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Su, Zhang, Gan, Jiang, Xiao, Zou, Li, Jiang: "Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." dans: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).

  • Antigène
    FZD3 (Frizzled Family Receptor 3 (FZD3))
    Autre désignation
    FZD3/Frizzled 3 (FZD3 Produits)
    Synonymes
    anticorps Fz-3, anticorps FZ-3, anticorps fz3, anticorps Xfz3, anticorps frz3, anticorps hfz3, anticorps frz-3, anticorps frizzled3, anticorps frizzled-3, anticorps FZD3, anticorps AU020229, anticorps D930050A07Rik, anticorps Fz3, anticorps fz9, anticorps fzd3, anticorps zg09, anticorps fzd3l, anticorps frizzled class receptor 3, anticorps frizzled class receptor 3 L homeolog, anticorps frizzled class receptor 3a, anticorps frizzled class receptor 3b, anticorps FZD3, anticorps fzd3, anticorps fzd3.L, anticorps Fzd3, anticorps fzd3a, anticorps fzd3b
    Sujet

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    Subcellular location: Cell membrane

    Synonyms: Fz-3, Frizzled-3, hFz3, FZD3

    ID gène
    7976
    UniProt
    Q9NPG1
    Pathways
    Signalisation WNT, Tube Formation
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