GUCA1B anticorps (AA 21-120)

N° du produit ABIN1714375

Cet anticorps Lapin Polyclonal détecte spécifiquement GUCA1B dans WB, ELISA, ICC, IF (cc), IF (p), IHC (fro) et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour GUCA1B anticorps (AA 21-120) (ABIN1714375)

Antigène: GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GUCA1B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GUCA1B anticorps

Épitope: AA 21-120

Homologie: Human,Mouse,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GCAP2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur GUCA1B

Antigène: GUCA1B (Guanylate Cyclase Activator 1B (Retina) (GUCA1B))

Autre désignation: GCAP2

Sujet:

Synonyms: GCAP 2, Guanylate Cyclase Activating Protein Photoreceptor 2, Guanylate Cyclase Activator 1B, Guanylin 2, Guanylyl cyclase-activating protein 2, GUC1B_HUMAN, GUCA 2, GUCA1B.

Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of cGMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90 % similar, consisting of 201 to 205 amino acids and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event. The genes which encode GCAP1 and GCAP2 map to human chromosome 6p21.1.

ID gène: 2979

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction