GRP78 anticorps

N° du produit ABIN1721537

L’anticorps Souris Monoclonal anti-GRP78 a été validé pour WB et ELISA. Il convient pour détecter GRP78 dans des échantillons de Humain, Rat, Souris, Grenouille, Xenopus laevis et Mammifères.

Aperçu rapide pour GRP78 anticorps (ABIN1721537)

Antigène: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Reactivité: Humain, Rat, Souris, Grenouille, Xenopus laevis, Mammifères

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRP78 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 6H4-2G7

Détail du produit anti-GRP78 anticorps

Specificité: Reacts with human GRP78. Cross-reacts with mouse, rat, bovine, hamster, rabbit, monkey, xenopus and fungi (Cryphonectria parasitica) protein.

Purification: Purified (protein G)

Immunogène: His-tagged human GRP78 (accession no. NP_001156906.1)

Isotype: IgG1

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB(0.5 - 1.0 μg/mL)

Positive control: HeLa cell

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2 mg/mL

Buffer: PBS, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Dilute in PBS or medium which is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.

Date de péremption: 6 months

Détails sur GRP78

Antigène: GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))

Autre désignation: GRP78

Sujet: Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer's disease patients.

78 kDa glucose-regulated protein, GRP-78 Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 Heat shock 70 kDa protein 5 Immunoglobulin heavy chain-binding protein, BiP Gene name: HSPA5, GRP78

ID gène: 3309

UniProt: P11021

Pathways: Thyroid Hormone Synthesis, ER-Nucleus Signaling