MSH2 anticorps

N° du produit ABIN1724643

Cet anticorps anti-MSH2 est un anticorps Souris Monoclonal détectant MSH2 dans WB, ELISA, IHC et ICC. Adapté pour Humain et Singe.

Aperçu rapide pour MSH2 anticorps (ABIN1724643)

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: 1B3A8A8

Détail du produit anti-MSH2 anticorps

Fonction: MSH2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human MSH2 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur MSH2

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Autre désignation: MSH2

Sujet: MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA
replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic
colorectal carcinoma. MSHS mutations are responsible for 50 % of inherited non-polyposis colorectal
(HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic
information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI).
These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.

Poids moléculaire: 105 kDa

ID gène: 4436

UniProt: P43246

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response