Chromogranin A anticorps (AA 87-252)

N° du produit ABIN1724756

L’anticorps Souris Monoclonal anti-Chromogranin A a été validé pour WB et ELISA. Il convient pour détecter Chromogranin A dans des échantillons de Humain et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour Chromogranin A anticorps (AA 87-252) (ABIN1724756)

Antigène: Chromogranin A (CHGA)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Chromogranin A est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1A6B6

Détail du produit anti-Chromogranin A anticorps

Épitope: AA 87-252

Fonction: CHGA Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CHGA (AA: 87-252 ) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Chromogranin A (ABIN1724756)

Mergler, Skrzypski, Sassek, Pietrzak, Pucci, Wiedenmann, Strowski: "Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells." dans: Cellular signalling, Vol. 24, Issue 1, pp. 233-46, (2011) (PubMed).

El Ali, Fichna, Piniewska, Kosowicz, Grzymis?awski: "Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease." dans: Journal of endocrinological investigation, Vol. 33, Issue 3, pp. 186-91, (2010) (PubMed).

Détails sur Chromogranin A

Antigène: Chromogranin A (CHGA)

Autre désignation: CHGA

Sujet: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides, vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.

Poids moléculaire: 50.7 kDa

ID gène: 1113

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling