WHSC2 anticorps (AA 280-511)

N° du produit ABIN1724801

L’anticorps Souris Monoclonal anti-WHSC2 a été validé pour WB, ELISA, IHC, FACS et ICC. Il convient pour détecter WHSC2 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour WHSC2 anticorps (AA 280-511) (ABIN1724801)

Antigène: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WHSC2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 6B11H8

Détail du produit anti-WHSC2 anticorps

Épitope: AA 280-511

Fonction: WHSC2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-WHSC2 (ABIN1724801)

Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." dans: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).

Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." dans: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).

Détails sur WHSC2

Antigène: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Autre désignation: WHSC2

Sujet: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Poids moléculaire: 57.3 kDa

ID gène: 7469

Pathways: Chromatin Binding