CD22 anticorps (AA 621-725)

N° du produit ABIN1724887

Cet anticorps Souris Monoclonal détecte spécifiquement CD22 dans FACS, ELISA et ICC. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour CD22 anticorps (AA 621-725) (ABIN1724887)

Antigène: CD22 (CD22 Molecule (CD22))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD22 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Clone: 1A3A11

Détail du produit anti-CD22 anticorps

Épitope: AA 621-725

Fonction: CD22 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD22 (AA: 621-725) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CD22 (ABIN1724887)

Tuscano, Kato, Pearson, Xiong, Newell, Ma, Gandara, ODonnell: "CD22 antigen is broadly expressed on lung cancer cells and is a target for antibody-based therapy." dans: Cancer research, Vol. 72, Issue 21, pp. 5556-65, (2012) (PubMed).

Kawasaki, Rademacher, Paulson: "CD22 regulates adaptive and innate immune responses of B cells." dans: Journal of innate immunity, Vol. 3, Issue 4, pp. 411-9, (2011) (PubMed).

Détails sur CD22

Antigène: CD22 (CD22 Molecule (CD22))

Autre désignation: CD22

Sujet: CD22 may be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules

Poids moléculaire: 95.3 kDa

ID gène: 933

UniProt: P20273