Transferrin Receptor anticorps (AA 608-727)

N° du produit ABIN1724899

Cet anticorps Souris Monoclonal détecte spécifiquement Transferrin Receptor dans WB et ELISA. Il présente une réactivité envers Humain, Souris, Rat et Singe et a été mentionné dans 2+ publications.

Aperçu rapide pour Transferrin Receptor anticorps (AA 608-727) (ABIN1724899)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1A1B2

Détail du produit anti-Transferrin Receptor anticorps

Épitope: AA 608-727

Fonction: TFRC Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Transferrin Receptor (ABIN1724899)

Płoszyńska, Ruckemann-Dziurdzińska, Jóźwik, Mikosik, Lisowska, Balcerska, Witkowski: "Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia." dans: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 50, Issue 2, pp. 304-11, (2012) (PubMed).

Jian, Yang, Huang: "Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival." dans: The Journal of biological chemistry, Vol. 286, Issue 41, pp. 35708-15, (2011) (PubMed).

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: TFRC

Sujet: Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses.

Poids moléculaire: 85 kDa

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis