MFN2 anticorps (AA 370-600) (Atto 390)

N° du produit ABIN1741234

Cet anticorps Souris Monoclonal détecte spécifiquement MFN2 dans WB, IHC, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour MFN2 anticorps (AA 370-600) (Atto 390) (ABIN1741234)

Antigène: MFN2 (Mitofusin 2 (MFN2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MFN2 est conjugé à/à la Atto 390

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: S153-5

Détail du produit anti-MFN2 anticorps (Atto 390)

Épitope: AA 370-600

Specificité: Detects ~90 kDa. No cross-reactivity against Mitofusin-1.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.

Isotype: IgG2a

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN1741234 was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur MFN2

Antigène: MFN2 (Mitofusin 2 (MFN2))

Autre désignation: Mitofusin 2

Sujet: Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.

ID gène: 170731

NCBI Accession: NP_573464

UniProt: Q80U63

Pathways: Skeletal Muscle Fiber Development