SHANK3 anticorps (C-Term)

N° du produit ABIN1742347

Cet anticorps Lapin Polyclonal détecte spécifiquement SHANK3 dans WB, ICC et IHC (fro). Il présente une réactivité envers Rat et Souris et a été mentionné dans 4+ publications.

Aperçu rapide pour SHANK3 anticorps (C-Term) (ABIN1742347)

Antigène: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHANK3 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Classe de qualité: KO Validated

Détail du produit anti-SHANK3 anticorps

Épitope: C-Term

Fonction: Rabbit anti-Shank3 antiserum

Specificité: Specific for shank 3.

Réactivité croisée (Details): Reacts with: rat (Q9JLU4), mouse (Q4ACU6). Other species not tested yet.

Purification: antiserum

Immunogène: Recombinant protein corresponding to residues near the carboxy terminus of rat Shank3 (UniProt Id: Q9JLU4)

Information d'application

Indications d'application: WB:1 : 1000

Commentaires:

IHC: For best results the antibody requires a mild fixation protocol (2 % PFA in sodium acetate buffer, pH 6).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 200 μLH2O, then aliquot and store at -20 °C until use.

Conseil sur la manipulation: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Stock: -20 °C,4 °C

Stockage commentaire: Antibodies should be stored at +4°C when still lyophilized. Do not freeze!

Références pour anticorps anti-SHANK3 (ABIN1742347)

Tao-Cheng, Toy, Winters, Reese, Dosemeci: "Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses." dans: PLoS ONE, Vol. 11, Issue 5, pp. e0153979, (2016) (PubMed).

Wei, Ma, Ding, Jin, Liu, Chang, Hu, Yu: "Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder." dans: Neurochemical research, Vol. 41, Issue 11, pp. 3129-3137, (2016) (PubMed).

Wei, Ma, Liu, Ding, Jin, Wang, Hu, Yu: "Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism." dans: Biochimica et biophysica acta, Vol. 1862, Issue 10, pp. 1918-25, (2016) (PubMed).

Hagmeyer, Mangus, Boeckers, Grabrucker: "Effects of trace metal profiles characteristic for autism on synapses in cultured neurons." dans: Neural plasticity, Vol. 2015, pp. 985083, (2015) (PubMed).

Détails sur SHANK3

Antigène: SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))

Autre désignation: Shank3

Sujet:

Synonyms: SPANK 3, Shanlk-3

Antigen Information: K.O. Shanks are multidomain proteins of the postsynaptic density

UniProt: Q9JLU4

Pathways: Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity