Podoplanin anticorps

N° du produit ABIN180856

Cet anticorps Rat Monoclonal détecte spécifiquement Podoplanin dans WB, FACS, IP, IHC (p) et IHC (fro). Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Podoplanin anticorps (ABIN180856)

Antigène: Podoplanin (PDPN)

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Podoplanin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: NZ-1

Détail du produit anti-Podoplanin anticorps

Specificité: The monoclonal antibody will detect Human Podoplanin on the surface of lymphatic endothelial cells and kidney podocytes. Therefore, it will be a useful tool to study lymphatic vessel density in and around Human tumors. Does not react with Mouse.

Attributs du produit: Synonyms: Glycoprotein 36, PA2.26 antigen, T1-alpha, Aggrus, PDPN, GP36, PSEC0003, PSEC0025

Purification: Purified

Isotype: IgG2a

Information d'application

Indications d'application: FACS (1/200). Western blot (>/= 1/200). Immunoprecipitation: 1/50. Immunostaining/Immunohistochemistry on Frozen and Paraffin Sections (1/200). Suitablefor Formalin-Fixed Paraffin Embedded Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in working aliquots) at -20 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-Podoplanin (ABIN180856)

Martín-Villar, Fernández-Muñoz, Parsons, Yurrita, Megías, Pérez-Gómez, Jones, Quintanilla: "Podoplanin associates with CD44 to promote directional cell migration." dans: Molecular biology of the cell, Vol. 21, Issue 24, pp. 4387-99, (2011) (PubMed).

Détails sur Podoplanin

Antigène: Podoplanin (PDPN)

Autre désignation: Podoplanin

Sujet: Podoplanin is a well-recognized lymphatic endothelium marker, which can be used to reliably distinguish lymphatic vessels from blood vessels. Podoplanin is a Mr 38,000 membrane mucoprotein that was originally detected on the surface of rat glomerular epithelial cells (podocytes) and was found to be linked to flattening of foot processes that occurs in glomerular diseases. Podoplanin shows features of a membrane mucoprotein with several conserved O-glycosylation sites. Currently, it is of unknown biological function. Because heavily O-glycosylated mucoproteins were identified recently as counterreceptors for selectins that mediate adhesion of inflammatory cells, it is possible that podoplanin plays a similar role in lymphatic endothelia.Synonyms: Aggrus, GP36, Glycoprotein 36, PA2.26 antigen, PDPN, PSEC0003, PSEC0025, T1-alpha

ID gène: 10630

UniProt: Q86YL7

Pathways: Dicarboxylic Acid Transport