Complement Factor I anticorps

N° du produit ABIN181115

L’anticorps anti-Complement Factor I Monoclonal Souris est utilisé pour la détection de Complement Factor I dans des échantillons de Humain. Il a été validé pour WB, EIA, IHC (fro) et Func.

Aperçu rapide pour Complement Factor I anticorps (ABIN181115)

Antigène: Complement Factor I (CFI)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement Factor I est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: 3R-8

Détail du produit anti-Complement Factor I anticorps

Specificité: This antibody recognises complement factor I, a member of the peptidase S1 family present in the blood plasma.

Attributs du produit: Synonyms: CFI, IF, KAF, AHUS3, C3BINA, C3b-INA, C3B/C4B inactivator

Purification: Affinity chromatography on Protein A

Immunogène: Native human factor I from serum.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/3000 - 1/4000. Western Blot. Functional Assays. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0mg/mL

Buffer: Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Complement Factor I

Antigène: Complement Factor I (CFI)

Autre désignation: Complement Factor I

Sujet: Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors. Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome.Synonyms: AHUS3, C3B/C4B inactivator, C3BINA, C3b-INA, CFI, IF, KAF

ID gène: 3426

UniProt: P05156

Pathways: Système du Complément