Cet anticorps Rat Monoclonal détecte spécifiquement TREM1 dans WB, FACS, IF, IHC (fro) et Func. Il présente une réactivité avec des échantillons de Souris.
Recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
Purification
Protein G purified
Immunogène
Mouse TREM-1 Fc fusion protein. ImmunogenType: Fusion protein