ABCA1 anticorps
Aperçu rapide pour ABCA1 anticorps (ABIN187475)
Antigène
Voir toutes ABCA1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Specificité
- Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder resulting from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. Species Human. Other species not tested.
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Immunogène
- Peptide corresponding to amino acids 1800-2260.
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Isotype
- IgG1
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Indications d'application
- Immunohistochemistry Western blot ELISA Immunoprecipitation The optimal dilution for a specific application should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 100 µg of antibody at 1 mg/mL in PBS, pH 7.4, with 0.5% sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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- ABCA1 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1))
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Autre désignation
- ABCA1
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Pathways
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism
Antigène
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